Modifying Pavlovian-to-instrumental transfer by approach avoidance training in healthy subjects: a proof of concept study.

ABSTRACT: The modulation of instrumental action by conditioned Pavlovian cues is hypothesized to play a role in the emergence and maintenance of maladaptive behavior. The Pavlovian to Instrumental transfer task (PIT) is designed to examine the magnitude of the influence of cues on behavior and we aim to manipulate the motivational value of Pavlovian cues to reduce their effect on instrumental responding. To this end, we utilized a joystick-based modification of approach and avoidance propensities that has shown success in clinical populations. To examine changes in PIT, we subjected 35 healthy participants to a series of experimental procedures: (1) Instrumental training was followed by (2) Pavlovian conditioning of neutral stimuli that were associated with monetary reward or loss. (3) In a subseque

SUBMITTER: Rosenthal A 

PROVIDER: S-EPMC10284857 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature