Human pluripotent stem cell (hPSC) and organoid models of autism: opportunities and limitations.

ABSTRACT: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder caused by genetic or environmental perturbations during early development. Diagnoses are dependent on the identification of behavioral abnormalities that likely emerge well after the disorder is established, leaving critical developmental windows uncharacterized. This is further complicated by the incredible clinical and genetic heterogeneity of the disorder that is not captured in most mammalian models. In recent years, advancements in stem cell technology have created the opportunity to model ASD in a human context through the use of pluripotent stem cells (hPSCs), which can be used to generate 2D cellular models as well as 3D unguided- and region-specific neural organoids. These models produce profoundly intricate s

SUBMITTER: Kilpatrick S 

PROVIDER: S-EPMC10284884 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature