The Effect of Biological Treatment on Fatigue in Inflammatory Bowel Disease: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Fatigue is a frequent complaint in patients with inflammatory bowel disease. Biological drugs have demonstrated beneficial effects on some extraintestinal manifestations, but the effect on fatigue is not clear.

Objective

This study investigated the effects of biological and small molecule drugs approved for inflammatory bowel disease on fatigue.

Methods

We performed a systematic review and meta-analysis of randomized, placebo-controlled trials reporting Federal Drug Agency (FDA)-approved biological and small molecule drugs for use in ulcerative colitis and Crohn's disease in which measures of fatigue were recorded before and after treatment. Only induction studies were included. Maintenance studies were excluded. We searched Embase (Ovid), Medline (Ovid), P

SUBMITTER: Skjellerudsveen BM 

PROVIDER: S-EPMC10284989 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature