Pharmacological targeting of gastric mucosal barrier with traditional Chinese medications for repairing gastric mucosal injury.

ABSTRACT: Introduction: The gastric mucosa (GM) is the first barrier and vital interface in the stomach that protects the host from hydrochloric acid in gastric juice and defends against exogenous insults to gastric tissues. The use of traditional Chinese medications (TCMs) for the treatment of gastric mucosal injury (GMI) has long-standing history and a good curative effect. Whereas there are poor overall reports on the intrinsic mechanisms of these TCM preparations that pharmacology uses to protect body from GMI, which is crucial to treating this disease. These existing reviews have deficiencies that limit the clinical application and development of both customary prescriptions and new drugs. Methods: Further basic and translational studies must be done to elucidate the intrinsic mec

SUBMITTER: Jia X 

PROVIDER: S-EPMC10285076 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature