The landscape of mitophagy in sepsis reveals PHB1 as an NLRP3 inflammasome inhibitor.

ABSTRACT: Mitophagy is a selective autophagy targeting damaged and potential cytotoxic mitochondria, which can effectively prevent excessive cytotoxic production from damaged mitochondria and alleviate the inflammatory response. However, the potential role of mitophagy in sepsis remains poorly explored. Here, we studied the role of mitophagy in sepsis and its immune heterogeneity. By performing mitophagy-related typing on 348 sepsis samples, three clusters (A, B, and C) were obtained. Cluster A had the highest degree of mitophagy accompanied by lowest disease severity, while cluster C had the lowest degree of mitophagy with the highest disease severity. The three clusters had unique immune characteristics. We further revealed that the expression of PHB1 in these three clusters was significantly diff

SUBMITTER: Chen S 

PROVIDER: S-EPMC10285102 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature