Identification and validation of G protein-coupled receptors modulating flow-dependent signaling pathways in vascular endothelial cells.

ABSTRACT: Vascular endothelial cells are exposed to mechanical forces due to their presence at the interface between the vessel wall and flowing blood. The patterns of these mechanical forces (laminar vs. turbulent) regulate endothelial cell function and play an important role in determining endothelial phenotype and ultimately cardiovascular health. One of the key transcriptional mediators of the positive effects of laminar flow patterns on endothelial cell phenotype is the zinc-finger transcription factor, krüppel-like factor 2 (KLF2). Given its importance in maintaining a healthy endothelium, we sought to identify endothelial regulators of the KLF2 transcriptional program as potential new therapeutic approaches to treating cardiovascular disease. Using an approach that utilized both bioinformatic

SUBMITTER: Qiu D 

PROVIDER: S-EPMC10285409 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature