Six potential biomarkers in septic shock: a deep bioinformatics and prospective observational study.

ABSTRACT:

Background

Septic shock occurs when sepsis is related to severe hypotension and leads to a remarkable high number of deaths. The early diagnosis of septic shock is essential to reduce mortality. High-quality biomarkers can be objectively measured and evaluated as indicators to accurately predict disease diagnosis. However, single-gene prediction efficiency is inadequate; therefore, we identified a risk-score model based on gene signature to elevate predictive efficiency.

Methods

The gene expression profiles of GSE33118 and GSE26440 were downloaded from the Gene Expression Omnibus (GEO) database. These two datasets were merged, and the differentially expressed genes (DEGs) were identified using the limma package in R software. Gene Ontology (GO) and Kyoto Encyclopedia of Gene

SUBMITTER: Kong C 

PROVIDER: S-EPMC10285480 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature