A versatile, bioengineered skin reconstruction device designed for use in austere environments.

ABSTRACT: Austere environments in which access to medical facilities, medical personnel, or even water and electricity is limited or unavailable pose unique challenges for medical device product design. Currently existing skin substitutes are severely inadequate for the treatment of severe burns, chronic wounds, battlefield injuries, or work-related injuries in resource-limited settings. For such settings, an ideal device should be biocompatible, bioresorbable, promote tissue healing, not require trained medical personnel for deployment and use, and should enable topical drug delivery. As proof of concept for such a device, silk fibroin and an antioxidant hyaluronic acid derivative were chosen as primary constituents. The final formulation was selected to optimize tensile strength while retaining me

SUBMITTER: Veit JGS 

PROVIDER: S-EPMC10285514 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature