High-definition Cathodal Direct Current Stimulation for Treatment of Acute Ischemic Stroke: A Randomized Clinical Trial.

ABSTRACT:

Importance

Cathodal transcranial direct current stimulation (C-tDCS) provides neuroprotection in preclinical models of acute ischemic stroke (AIS) by inhibiting peri-infarct excitotoxic effects and enhancing collateral perfusion due to its vasodilatory properties.

Objective

To report the first-in-human pilot study using individualized high-definition (HD) C-tDCS as a treatment of AIS.

Design, setting, and participants

This randomized clinical trial was sham controlled with 3 + 3 dose escalation design, and was conducted at a single center from October 2018 to July 2021. Eligible participants were treated for AIS within 24 hours from onset, had imaging evidence of cortical ischemia with salvageable penumbra, and were ineligible for reperfusion therapies. HD C-tDCS elec

SUBMITTER: Bahr-Hosseini M 

PROVIDER: S-EPMC10285579 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature