Elevated Serum IL-2 Levels are Associated With Major Depressive Disorder: A Case-Control Study.

ABSTRACT:

Objectives

Numerous earlier studies have stated an association between major depressive disorder (MDD) and altered expression of inflammatory process. However, it still needs to determine whether the alteration of cytokines is the causative factor or a consequence of this disorder. Therefore, we attempted to evaluate the role of the pro-inflammatory cytokine IL-2 in the pathophysiology of depression.

Methods

We collected blood samples from 111 MDD patients and 112 healthy controls (HCs) matched by age and sex. Diagnostic and statistical manual of mental disorders (DSM-5) score was used to assess study participants. We determined the severity of depression using the Hamilton Depression (Ham-D) rating scale. We assayed serum levels of IL-2 using the Enzyme-Linked Immunosorbent

SUBMITTER: Suhee FI 

PROVIDER: S-EPMC10285590 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature