Ontology highlight
ABSTRACT:
SUBMITTER: Benadda S
PROVIDER: S-EPMC10285637 | biostudies-literature | 2023 Jul
REPOSITORIES: biostudies-literature
Benadda Samira S Nugue Mathilde M Koumantou Despoina D Bens Marcelle M De Luca Mariacristina M Pellé Olivier O Monteiro Renato C RC Evnouchidou Irini I Saveanu Loredana L
iScience 20230609 7
Cell surface receptor internalization can either terminate signaling or activate alternative endosomal signaling pathways. We investigated here whether endosomal signaling is involved in the function of the human receptors for Fc immunoglobulin fragments (FcRs): FcαRI, FcγRIIA, and FcγRI. All these receptors were internalized after their cross-linking with receptor-specific antibodies, but their intracellular trafficking was different. FcαRI was targeted directly to lysosomes, while FcγRIIA and ...[more]