Analysis of intervertebral disc CCR6 and IL-6 gene levels with short-term postoperative low back pain after spinal fusion in lumbar degenerative disease.

ABSTRACT:

Background

Previous studies have reported that specific pro-inflammatory cytokines or chemokines are more highly expressed in painful than in nonpainful intervertebral discs (IVDs). However, few studies have investigated their correlation with postsurgical outcomes or the relationship between postoperative pain and inflammatory cytokines in IVDs. Thus, the present study examined the correlation among the gene expression levels of pro-inflammatory cytokines and chemokines in IVD tissues removed during surgery and low back pain (LBP), leg pain (LP), and leg numbness (LN) at one year after spinal fusion surgery in patients with a lumbar degenerative disease (LDD).

Methods

Chemokine and cytokine gene expression levels were measured in IVD samples from 48 patients with LDD. The a

SUBMITTER: Hiyama A 

PROVIDER: S-EPMC10285749 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature