Visible and NIR light photoactivatable o-hydroxycinnamate system for efficient drug release with fluorescence monitoring.

ABSTRACT: Photoactivatable protecting groups (PPGs) have become powerful materials for controlling the activity of biologically important molecules in the biomedical field. However, designing PPGs that can be efficiently activated by biologically benign visible and NIR light with fluorescence monitoring is still a great challenge. Herein, we report o-hydroxycinnamate-based PPGs that can be activated by both visible (one-photon) and NIR (two-photon) light for controlled drug release with real-time monitoring. Thus, a photoremovable 7-diethylamino o-hydroxycinnamate group is covalently attached to an anticancer drug, gemcitabine, to establish a photoactivatable prodrug system. Upon excitation by visible (400-700 nm) or NIR (800 nm) light, the prodrug efficiently releases drug which is qu

SUBMITTER: Gupta A 

PROVIDER: S-EPMC10285768 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature