Functionalized Magnetic Nanoparticles for NIR-Induced Photothermal Therapy of Potential Application in Cervical Cancer.

ABSTRACT: Photothermal therapy (PTT) holds great promise for cancer treatment with its effective ablation of solid tumors. As the essential core point, photothermal agents (PTAs) with excellent photothermal properties and good biocompatibility could help to fulfill highly efficient PTT. Herein, a novel type of nanoplatform Fe₃O₄@PDA/ICG (FPI) nanoparticle (NP) was designed and synthesized, which was composed of magnetic Fe₃O₄ and near-infrared excitable indocyanine green via encapsulation of polydopamine. The FPI NPs showed spherical structures in shape with uniform distribution and good chemical stability. Under 793 nm laser irradiation, FPI NPs could generate hyperthermia of 54.1 °C and photothermal conversion efficiency of 35.21%. The low cytotoxicity o

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10286267 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature