Characterization and evaluation of gene fusions as a measure of genetic instability and disease prognosis in prostate cancer.

ABSTRACT:

Background

Prostate cancer (PCa) is one of the most prevalent cancers worldwide. The clinical manifestations and molecular characteristics of PCa are highly variable. Aggressive types require radical treatment, whereas indolent ones may be suitable for active surveillance or organ-preserving focal therapies. Patient stratification by clinical or pathological risk categories still lacks sufficient precision. Incorporating molecular biomarkers, such as transcriptome-wide expression signatures, improves patient stratification but so far excludes chromosomal rearrangements. In this study, we investigated gene fusions in PCa, characterized potential novel candidates, and explored their role as prognostic markers for PCa progression.

Methods

We analyzed 630 patients in four cohort

SUBMITTER: Schimmelpfennig C 

PROVIDER: S-EPMC10286324 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature