Varied hypoxia adaptation patterns of embryonic brain at different development stages between Tibetan and Dwarf laying chickens.

ABSTRACT:

Background

Tibetan chickens (Gallus gallus; TBCs), an indigenous breed distributed in the Qinghai-Tibet Plateau, are well adapted to the hypoxic environment. Currently, the molecular genetic basis of hypoxia adaptation in TBCs remains unclear. This study investigated hypoxia adaptation patterns of embryonic brain at different development stages by integrating analysis of the transcriptome with our previously published metabolome data in TBCs and Dwarf Laying Chickens (DLCs), a lowland chicken breed.

Results

During hypoxia, the results revealed that 1334, 578, and 417 differentially expressed genes (DEGs) (|log₂ fold change|>1, p-value < 0.05) on days 8, 12, and 18 of development, respectively between TBCs and DLCs. Gene Ontology (GO) and pathway analyses revealed

SUBMITTER: Tang Q 

PROVIDER: S-EPMC10286358 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature