Gut microbiota mediated the therapeutic efficiency of Simiao decoction in the treatment of gout arthritis mice.

ABSTRACT:

Background

Gut microbiota plays a significant role in the development and treatment of gouty arthritis. Simiao decoction has been shown to alleviate gouty arthritis by inhibiting inflammation, regulating NLRP3 inflammasome, and altering gut microbiota. However, there is no evidence to prove whether gut microbiota directly mediates the therapeutic efficiency of Simiao decoction in treating gout arthritis.

Methods

In this study, fecal microbiota transplantation (FMT) was used to transfer the gut microbiota of gout arthritis mice treated with Simiao decoction or allopurinol to blank gout arthritis mice, in order to investigate whether FMT had therapeutic effects on gout arthritis.

Results

Both Simiao decoction and allopurinol effectively reduced the levels of serum uric

SUBMITTER: Lin X 

PROVIDER: S-EPMC10286402 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature