HOPX is a tumor-suppressive biomarker that corresponds to T cell infiltration in skin cutaneous melanoma.

ABSTRACT:

Background

Skin cutaneous melanoma (SKCM) is the most threatening type of skin cancer. Approximately 55,000 people lose their lives every year due to SKCM, illustrating that it seriously threatens human life and health. Homeodomain-only protein homeobox (HOPX) is the smallest member of the homeodomain family and is widely expressed in a variety of tissues. HOPX is involved in regulating the homeostasis of hematopoietic stem cells and is closely related to the development of tumors such as breast cancer, nasopharyngeal carcinoma, and head and neck squamous cell carcinoma. However, its function in SKCM is unclear, and further studies are needed.

Methods

We used the R language to construct ROC (Receiver-Operating Characteristic) curves, KM (Kaplan‒Meier) curves and nomograms ba

SUBMITTER: He S 

PROVIDER: S-EPMC10286411 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature