Current status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors.

ABSTRACT: Diseases affecting the esophagus are common. However, targeted drug delivery to the esophagus is challenging due to the anatomy and physiology of this organ. Current pharmacological treatment for esophageal diseases predominantly relies on the off-label use of drugs in various dosage forms, including those for systemic drug delivery (e.g. oral tablets, sublingual tablets, and injections) and topical drug delivery (e.g. metered dose inhaler, viscous solution or suspension, and endoscopic injection into the esophagus). In general, systemic therapy has shown the most efficacy but requires the use of high drug doses to achieve effective concentrations in the esophagus, which increases the risk of adverse effects and toxicity. Topical drug delivery has enormous potential in improving the way we

SUBMITTER: Lim AW 

PROVIDER: S-EPMC10286676 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature