Glycosphingolipid Changes in Plasma in Parkinson's Disease Independent of Glucosylceramide Levels.

ABSTRACT:

Background

Alteration in glycosphingolipids (GSLs) in Parkinson's disease (PD) still needs to be determined.

Objectives

We evaluated if PD subjects show abnormal GSLs levels compared to healthy controls (HC) and if GSLs correlate with clinical features.

Methods

We analyzed GSLs and glucosylceramide (GlcCer) in plasma using two normal-phase high-performance liquid chromatography assays; clinico-demographic data were extracted.

Results

Eighty PD subjects and 25 HCs were analyzed. Levels of GlcCer, GD1b, Gb4, GalNAcGA1, and b-series were higher in PD patients than in HCs; total GSLs, GT1b, GM1a, GM3, GM2, and a-series levels were lower in PD patients than in HCs. Changes in GSLs were present in PD subjects, with GlcCer levels similar to those in HCs. The results w

SUBMITTER: Te Vruchte D 

PROVIDER: S-EPMC10286748 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature