A person-centered data analytic approach to dopaminergic polygenic moderation of child maltreatment exposure.

ABSTRACT: The present study illustrates the utility of latent class analysis, a person-centered data analytic approach, as an innovative method for identifying naturally occurring patterns of polygenic risk, specifically within the dopaminergic system. Moreover, this study tests whether latent classes of polygenic variation moderate the effect of child maltreatment exposure on internalizing symptoms among African ancestry youth. African ancestry youth were selected for this study because youth of color are overrepresented in the child welfare system and because African ancestry individuals are significantly underrepresented in genomics research. Results identified three latent classes of dopaminergic gene variation. Class 1 was marked predominately by homozygous minor alleles, Class 2 was characteri

SUBMITTER: Handley ED 

PROVIDER: S-EPMC10287038 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature