Association of genetically-predicted placental gene expression with adult blood pressure traits.

ABSTRACT:

Objective

Blood pressure is a complex, polygenic trait, and the need to identify prehypertensive risks and new gene targets for blood pressure control therapies or prevention continues. We hypothesize a developmental origins model of blood pressure traits through the life course where the placenta is a conduit mediating genomic and nongenomic transmission of disease risk. Genetic control of placental gene expression has recently been described through expression quantitative trait loci (eQTL) studies which have identified associations with childhood phenotypes.

Methods

We conducted a transcriptome-wide gene expression analysis estimating the predicted gene expression of placental tissue in adult individuals with genome-wide association study (GWAS) blood pressure summary sta

SUBMITTER: Hellwege JN 

PROVIDER: S-EPMC10287061 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature