Nova proteins direct synaptic integration of somatostatin interneurons through activity-dependent alternative splicing.

ABSTRACT: Somatostatin interneurons are the earliest born population of cortical inhibitory cells. They are crucial to support normal brain development and function; however, the mechanisms underlying their integration into nascent cortical circuitry are not well understood. In this study, we begin by demonstrating that the maturation of somatostatin interneurons in mouse somatosensory cortex is activity dependent. We then investigated the relationship between activity, alternative splicing, and synapse formation within this population. Specifically, we discovered that the Nova family of RNA-binding proteins are activity-dependent and are essential for the maturation of somatostatin interneurons, as well as their afferent and efferent connectivity. Within this population, Nova2 preferentially mediat

SUBMITTER: Ibrahim LA 

PROVIDER: S-EPMC10287156 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature