Glial-dependent clustering of voltage-gated ion channels in Drosophila precedes myelin formation.

ABSTRACT: Neuronal information conductance often involves the transmission of action potentials. The spreading of action potentials along the axonal process of a neuron is based on three physical parameters: the axial resistance of the axon, the axonal insulation by glial membranes, and the positioning of voltage-gated ion channels. In vertebrates, myelin and channel clustering allow fast saltatory conductance. Here, we show that in Drosophila melanogaster voltage-gated sodium and potassium channels, Para and Shal, co-localize and cluster in an area resembling the axon initial segment. The local enrichment of Para but not of Shal localization depends on the presence of peripheral wrapping glial cells. In larvae, relatively low levels of Para channels are needed to allow proper signal transduc

SUBMITTER: Rey S 

PROVIDER: S-EPMC10287160 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature