Negative Symptom Trajectories in Individuals at Clinical High Risk for Psychosis: Differences Based on Deficit Syndrome, Persistence, and Transition Status.

ABSTRACT:

Background and hypothesis

Negative symptom trajectory in clinical high risk (CHR) for psychosis is ill defined. This study aimed to better characterize longitudinal patterns of change in negative symptoms, moderators of change, and differences in trajectories according to clinical subgroups. We hypothesized that negative symptom course will be nonlinear in CHR. Clinical subgroups known to be more severe variants of psychotic illness-deficit syndrome (DS), persistent negative syndrome (PNS), and acute psychosis onset-were expected to show more severe baseline symptoms, slower rates of change, and less stable rates of symptom resolution.

Study design

Linear, curvilinear, and stepwise growth curve models, with and without moderators, were fitted to negative symptom ratings from

SUBMITTER: Tran T 

PROVIDER: S-EPMC10287168 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature