Quiescence during burst suppression and postictal generalized EEG suppression are distinct patterns of activity.

ABSTRACT:

Objective

Periods of low-amplitude electroencephalographic (EEG) signal (quiescence) are present during both anesthetic-induced burst suppression (BS) and postictal generalized electroencephalographic suppression (PGES). PGES following generalized seizures induced by electroconvulsive therapy (ECT) has been previously linked to antidepressant response. The commonality of quiescence during both BS and PGES motivated trials to recapitulate the antidepressant effects of ECT using high doses of anesthetics. However, there have been no direct electrographic comparisons of these quiescent periods to address whether these are distinct entities.

Methods

We compared periods of EEG quiescence recorded from two human studies: BS induced in 29 healthy adult volunteers by isoflurane gene

SUBMITTER: Kafashan M 

PROVIDER: S-EPMC10287541 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature