Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis.

ABSTRACT: Primary sclerosing cholangitis (PSC) is an immune-mediated disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication of patients with PSC and IBD, and these patients are at a much greater risk compared to patients with IBD without concomitant PSC. Combining flow cytometry, bulk and single-cell transcriptomics, and T and B cell receptor repertoire analysis of right colon tissue from 65 patients with PSC, 108 patients with IBD and 48 healthy individuals we identified a unique adaptive inflammatory transcriptional signature associated with greater risk and shorter time to dysplasia in patients with PSC. This inflammatory signature is characterized by antigen-driven interleukin-17A (IL-17A)⁺ forkh

SUBMITTER: Shaw DG 

PROVIDER: S-EPMC10287559 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature