Microstructural changes precede depression in patients with relapsing-remitting Multiple Sclerosis.

ABSTRACT:

Background

Multiple Sclerosis lesions in the brain and spinal cord can lead to different symptoms, including cognitive and mood changes. In this study we explore the temporal relationship between early microstructural changes in subcortical volumes and cognitive and emotional function in a longitudinal cohort study of patients with relapsing-remitting Multiple Sclerosis.

Methods

In vivo imaging in forty-six patients with relapsing-remitting Multiple Sclerosis was performed annually over 3 years magnetic resonance imaging. Microstructural changes were estimated in subcortical structures using the free water fraction, a diffusion-based MRI metric. In parallel, patients were assessed with the Hospital Anxiety and Depression Scale amongst other tests. Predictive structural equat

SUBMITTER: Riemer F 

PROVIDER: S-EPMC10287644 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature