Four-dimensional mapping of dynamic longitudinal brain subcortical development and early learning functions in infants.

ABSTRACT: Brain subcortical structures are paramount in many cognitive functions and their aberrations during infancy are predisposed to various neurodevelopmental and neuropsychiatric disorders, making it highly essential to characterize the early subcortical normative growth patterns. This study investigates the volumetric development and surface area expansion of six subcortical structures and their associations with Mullen scales of early learning by leveraging 513 high-resolution longitudinal MRI scans within the first two postnatal years. Results show that (1) each subcortical structure (except for the amygdala with an approximately linear increase) undergoes rapid nonlinear volumetric growth after birth, which slows down at a structure-specific age with bilaterally similar developmental patte

SUBMITTER: Chen L 

PROVIDER: S-EPMC10287661 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature