Anxiety in synucleinopathies: neuronal circuitry, underlying pathomechanisms and current therapeutic strategies.

ABSTRACT: Synucleinopathies are neurodegenerative disorders characterized by alpha-synuclein (αSyn) accumulation in neurons or glial cells, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). αSyn-related pathology plays a critical role in the pathogenesis of synucleinopathies leading to the progressive loss of neuronal populations in specific brain regions and the development of motor and non-motor symptoms. Anxiety is among the most frequent non-motor symptoms in patients with PD, but it remains underrecognized and undertreated, which significantly reduces the quality of life for patients. Anxiety is defined as a neuropsychiatric complication with characteristics such as nervousness, loss of concentration, and sweating due to the anticipation of

SUBMITTER: Lai TT 

PROVIDER: S-EPMC10287685 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature