Specific post-translational modifications of soluble tau protein distinguishes Alzheimer's disease and primary tauopathies.

ABSTRACT: Tau protein aggregates in several neurodegenerative disorders, referred to as tauopathies. The tau isoforms observed in post mortem human brain aggregates is used to classify tauopathies. However, distinguishing tauopathies ante mortem remains challenging, potentially due to differences between insoluble tau in aggregates and soluble tau in body fluids. Here, we demonstrated that tau isoforms differ between tauopathies in insoluble aggregates, but not in soluble brain extracts. We therefore characterized post-translational modifications of both the aggregated and the soluble tau protein obtained from post mortem human brain tissue of patients with Alzheimer's disease, cortico-basal degeneration, Pick's disease, and frontotemporal lobe degeneration. We found specific soluble signatures for

SUBMITTER: Kyalu Ngoie Zola N 

PROVIDER: S-EPMC10287718 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature