The Drosophila gene encoding JIG protein (CG14850) is critical for CrebA nuclear trafficking during development.

ABSTRACT: Coordination of mitochondrial and nuclear processes is key to the cellular health; however, very little is known about the molecular mechanisms regulating nuclear-mitochondrial crosstalk. Here, we report a novel molecular mechanism controlling the shuttling of CREB (cAMP response element-binding protein) protein complex between mitochondria and nucleoplasm. We show that a previously unknown protein, herein termed as Jig, functions as a tissue-specific and developmental timing-specific coregulator in the CREB pathway. Our results demonstrate that Jig shuttles between mitochondria and nucleoplasm, interacts with CrebA protein and controls its delivery to the nucleus, thus triggering CREB-dependent transcription in nuclear chromatin and mitochondria. Ablating the expression of Jig prevents Cr

SUBMITTER: Bhuiyan SH 

PROVIDER: S-EPMC10287909 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature