Dicodon-based measures for modeling gene expression.

ABSTRACT:

Motivation

Codon usage preference patterns have been associated with modulation of translation efficiency, protein folding, and mRNA decay. However, new studies support that codon pair usage has also a remarkable effect at the gene expression level. Here, we expand the concept of CAI to answer if codon pair usage patterns can be understood in terms of codon usage bias, or if they offer new information regarding coding translation efficiency.

Results

Through the implementation of a weighting strategy to consider the dicodon contributions, we observe that the dicodon-based measure has greater correlations with gene expression level than CAI. Interestingly, we have noted that dicodons associated with a low value of adaptiveness are related to dicodons which mediate strong trans

SUBMITTER: Alonso AM 

PROVIDER: S-EPMC10287933 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature