Identification of PTPN20 as an innate immunity-related gene in gastric cancer with Helicobacter pylori infection.

ABSTRACT:

Background

Gastric cancer (GC) is among the deadliest diseases with countless incidences and deaths each year. Helicobacter pylori (Hp) is the primary type of microbe that colonizes the stomach. In recent years, increasing evidence has demonstrated that Hp infection is one of the main risk factors for GC. Elucidating the molecular mechanism of how Hp leads to GC will not only benefit the treatment of GC, but also boost the development of therapeutics for other gastric disorders caused by Hp infection. In this study, we aimed to identify innate immunity-related genes in GC and investigate their potentials as prognostic markers and therapeutic targets for Hp-related GC.

Methods

Firstly, we analyzed the differentially expressed innate immunity-related genes in GC samples

SUBMITTER: Ma L 

PROVIDER: S-EPMC10287967 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature