Neural stem cell self-renewal stimulation by store-operated calcium entries in adult mouse area postrema: influence of leptin.

ABSTRACT: Neural stem cells (NSCs) persist in specific brain germinative niches and sustain neurogenesis throughout life in adult mammals. In addition to the two major stem cell niches in the subventricular zone and the hippocampal dentate gyrus, the area postrema located in the brainstem has been identified as a neurogenic zone as well. NSCs are regulated by signals from the microenvironment that adjust stem cell response to the needs of the organism. Evidence accumulated over the past decade indicates that Ca²⁺ channels play pivotal functions in NSC maintenance. In this study, we explored in area postrema NSCs the presence and roles of a subset of Ca²⁺ channels, the store-operated Ca²⁺ channels (SOCs) that have the capacity to transduce extracellular signals into C

SUBMITTER: Ben Dhaou C 

PROVIDER: S-EPMC10287973 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature