Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections.

ABSTRACT: A one-health perspective may provide new and actionable information about Escherichia coli transmission. E. coli colonizes a broad range of vertebrates, including humans and food-production animals, and is a leading cause of bladder, kidney, and bloodstream infections in humans. Substantial evidence supports foodborne transmission of pathogenic E. coli strains from food animals to humans. However, the relative contribution of foodborne zoonotic E. coli (FZEC) to the human extraintestinal disease burden and the distinguishing characteristics of such strains remain undefined. Using a comparative genomic analysis of a large collection of contemporaneous, geographically-matched clinical and meat-source E. coli isolates (n = 3111), we identified 17 sour

SUBMITTER: Liu CM 

PROVIDER: S-EPMC10288061 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature