Exploring the potential mechanisms of Shiwei Hezi pill against nephritis based on the method of network pharmacology.

ABSTRACT: Objective: We aimed to reveal the potential active ingredients, targets and pathways of Shiwei Hezi pill (SHP) in the treatment of nephritis based on systematic network pharmacology. Methods: The online database was used to screen the common targets of SHP and nephritis, and the interaction between targets was analyzed. Gene Ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed using the Bioinformatics website. Molecular docking was carried out to verify the correlation between core ingredients and key targets. Cytoscape 3.6.1 was applied to perform protein-protein interactions (PPT) network construction and data visualization. Results: A total of 82 active ingredients in SHP were screened, and

SUBMITTER: Wei L 

PROVIDER: S-EPMC10288138 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature