Ontology highlight
ABSTRACT:
SUBMITTER: Lawrence ECN
PROVIDER: S-EPMC10288152 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Lawrence Emily C N ECN Guo Michelle M Schwartz Turner D TD Wu Jie J Lu Jingwen J Nikonov Sergei S Sterling Jacob K JK Cui Qi N QN
Frontiers in cellular neuroscience 20230609
Glaucomatous neurodegeneration, a blinding disease affecting millions worldwide, has a need for the exploration of new and effective therapies. Previously, the glucagon-like peptide-1 receptor (GLP-1R) agonist NLY01 was shown to reduce microglia/macrophage activation, rescuing retinal ganglion cells after IOP elevation in an animal model of glaucoma. GLP-1R agonist use is also associated with a reduced risk for glaucoma in patients with diabetes. In this study, we demonstrate that several commer ...[more]