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Topical and systemic GLP-1R agonist administration both rescue retinal ganglion cells in hypertensive glaucoma.


ABSTRACT: Glaucomatous neurodegeneration, a blinding disease affecting millions worldwide, has a need for the exploration of new and effective therapies. Previously, the glucagon-like peptide-1 receptor (GLP-1R) agonist NLY01 was shown to reduce microglia/macrophage activation, rescuing retinal ganglion cells after IOP elevation in an animal model of glaucoma. GLP-1R agonist use is also associated with a reduced risk for glaucoma in patients with diabetes. In this study, we demonstrate that several commercially available GLP-1R agonists, administered either systemically or topically, hold protective potential in a mouse model of hypertensive glaucoma. Further, the resulting neuroprotection likely occurs through the same pathways previously shown for NLY01. This work contributes to a growing body of evidence suggesting that GLP-1R agonists represent a viable therapeutic option for glaucoma.

SUBMITTER: Lawrence ECN 

PROVIDER: S-EPMC10288152 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Topical and systemic GLP-1R agonist administration both rescue retinal ganglion cells in hypertensive glaucoma.

Lawrence Emily C N ECN   Guo Michelle M   Schwartz Turner D TD   Wu Jie J   Lu Jingwen J   Nikonov Sergei S   Sterling Jacob K JK   Cui Qi N QN  

Frontiers in cellular neuroscience 20230609


Glaucomatous neurodegeneration, a blinding disease affecting millions worldwide, has a need for the exploration of new and effective therapies. Previously, the glucagon-like peptide-1 receptor (GLP-1R) agonist NLY01 was shown to reduce microglia/macrophage activation, rescuing retinal ganglion cells after IOP elevation in an animal model of glaucoma. GLP-1R agonist use is also associated with a reduced risk for glaucoma in patients with diabetes. In this study, we demonstrate that several commer  ...[more]

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