Causal association between metabolic syndrome and cholelithiasis: a Mendelian randomization study.

ABSTRACT:

Background

Metabolic syndrome (MetS) has been associated with digestive system diseases, and recent observational studies have suggested an association between MetS and cholelithiasis. However, the causal relationship between them remains unclear. This study aimed to assess the causal effect of MetS on cholelithiasis using Mendelian randomization (MR) analysis.

Methods

Single nucleotide polymorphisms (SNPs) of MetS and its components were extracted from the public genetic variation summary database. The inverse variance weighting method (IVW), weighted median method, and MR-Egger regression were used to evaluate the causal relationship. A sensitivity analysis was performed to ensure the stability of the results.

Results

IVW showed that MetS increased the risk of chole

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC10288183 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature