Sympathetic Innervation Regulates Osteocyte-Mediated Cortical Bone Resorption during Lactation.

ABSTRACT: Bone undergoes constant remodeling by osteoclast bone resorption coupled with osteoblast bone formation at the bone surface. A third major cell type in the bone is osteocytes, which are embedded in the matrix, are well-connected to the lacunar network, and are believed to act as mechanical sensors. Here, it is reported that sympathetic innervation directly regulates lacunar osteocyte-mediated bone resorption inside cortical bone. It is found that sympathetic activity is elevated in different mouse models of bone loss, including lactation, ovariectomy, and glucocorticoid treatment. Further, during lactation elevated sympathetic outflow induces netrin-1 expression by osteocytes to further promote sympathetic nerve sprouting in the cortical bone endosteum in a feed-forward loop. Depletion of

SUBMITTER: Guo Q 

PROVIDER: S-EPMC10288263 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature