A Clinical-Scale Microfluidic Respiratory Assist Device with 3D Branching Vascular Networks.

ABSTRACT: Recent global events such as COVID-19 pandemic amid rising rates of chronic lung diseases highlight the need for safer, simpler, and more available treatments for respiratory failure, with increasing interest in extracorporeal membrane oxygenation (ECMO). A key factor limiting use of this technology is the complexity of the blood circuit, resulting in clotting and bleeding and necessitating treatment in specialized care centers. Microfluidic oxygenators represent a promising potential solution, but have not reached the scale or performance required for comparison with conventional hollow fiber membrane oxygenators (HFMOs). Here the development and demonstration of the first microfluidic respiratory assist device at a clinical scale is reported, demonstrating efficient oxygen transfer at bl

SUBMITTER: Isenberg BC 

PROVIDER: S-EPMC10288269 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature