Assessment of dependence potential and abuse liability of Δ⁸-tetrahydrocannabinol in mice.

ABSTRACT: Delta-8-tetrahydrocannabinol (Δ⁸-THC) is a psychotropic cannabinoid produced in low quantities in the cannabis plant. Refinements in production techniques, paired with the availability of inexpensive cannabidiol substrate, have resulted in Δ⁸-THC being widely marketed as a quasi-legal, purportedly milder alternative to Δ⁹-THC. Yet, little research has probed the behavioral and physiological effects of repeated Δ⁸-THC use. The present study aimed to evaluate the effects of acute and repeated exposure to Δ⁸-THC. We hypothesized that Δ⁸-THC produces effects similar to Δ⁹-THC, including signs of drug tolerance and dependence. Adult male and female C57BL/6J mice were treated acutely with Δ⁸-THC (6.25-100 mg/

SUBMITTER: Vanegas SO 

PROVIDER: S-EPMC10288383 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature