Hydrolytically Degradable Microgels with Tunable Mechanical Properties Modulate the Host Immune Response.

ABSTRACT: Hydrogel microparticles (microgels) are an attractive approach for therapeutic delivery because of their modularity, injectability, and enhanced integration with the host tissue. Multiple microgel fabrication strategies and chemistries have been implemented, yet manipulation of microgel degradability and its effect on in vivo tissue responses remains underexplored. Here, the authors report a facile method to synthesize microgels crosslinked with ester-containing junctions to afford tunable degradation kinetics. Monodisperse microgels of maleimide-functionalized poly(ethylene-glycol) are generated using droplet microfluidics crosslinked with thiol-terminated, ester-containing molecules. Tunable mechanics are achievable based on the ratio of degradable to nondegradable crosslinkers in the co

SUBMITTER: Coronel MM 

PROVIDER: S-EPMC10288386 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature