Joint use of population pharmacokinetics and machine learning for optimizing antiepileptic treatment in pediatric population.

ABSTRACT:

Purpose

Unpredictable drug efficacy and safety of combined antiepileptic therapy is a major challenge during pharmacotherapy decisions in everyday clinical practice. The aim of this study was to describe the pharmacokinetics of valproic acid (VA), lamotrigine (LTG), and levetiracetam (LEV) in a pediatric population using nonlinear mixed-effect modeling, while machine learning (ML) algorithms were applied to identify any relationships among the plasma levels of the three medications and patients' characteristics, as well as to develop a predictive model for epileptic seizures.

Methods

The study included 71 pediatric patients of both genders, aged 2-18 years, on combined antiepileptic therapy. Population pharmacokinetic (PopPK) models were developed separately for VA, LTG, and

SUBMITTER: Damnjanovic I 

PROVIDER: S-EPMC10288421 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature