Adverse Gastrointestinal Events With Sodium Polystyrene Sulfonate Use in Patients on Maintenance Hemodialysis: An International Cohort Study.

ABSTRACT:

Background

There are concerns regarding the gastrointestinal (GI) safety of sodium polystyrene sulfonate (SPS), a medication commonly used in the management of hyperkalemia.

Objective

To compare the risk of GI adverse events among users versus non-users of SPS in patients on maintenance hemodialysis.

Design

International prospective cohort study.

Setting

Seventeen countries (Dialysis Outcomes and Practice Patterns Study [DOPPS] phase 2-6 from 2002 to 2018).

Patients

50 147 adults on maintenance hemodialysis.

Measurements

An adverse GI event defined by a GI hospitalization or GI fatality with SPS prescription compared with no SPS prescription.

Methods

Overlap propensity score-weighted Cox models.

Results

Sodium polystyrene sulfonate p

SUBMITTER: Farfan Ruiz AC 

PROVIDER: S-EPMC10288443 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature