Circulating DNA methylation level of CXCR5 correlates with inflammation in patients with rheumatoid arthritis.

ABSTRACT:

Objectives

To assess the differences in circulating DNA methylation levels of CXCR5 between rheumatoid arthritis (RA) and osteoarthritis (OA) and healthy controls (HC), and the correlation of methylation changes with clinical characteristics of RA patients.

Methods

Peripheral blood samples were collected from 239 RA patients, 30 patients with OA, and 29 HC. Target region methylation sequencing to the promoter region of CXCR5 was achieved using MethylTarget. The methylation level of cg04537602 and methylation haplotype were compared among the three groups, and the correlation between methylation levels and clinical characteristics of RA patients was performed by Spearman's rank correlation analysis.

Results

The methylation level of cg04537602 was significantly higher i

SUBMITTER: Shi Y 

PROVIDER: S-EPMC10288483 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature