Template-Based Porous Hydrogel Microparticles as Carriers for Therapeutic Proteins.

ABSTRACT: Hydrogels have been extensively researched for over 60 years for their limitless applications in biomedical research. In this study, porous hydrogel microparticles (PHMPs) made of poly(ethylene glycol) diacrylamide were investigated for their potential as a delivery platform for therapeutic proteins. These particles are made using hard calcium carbonate (CaCO₃) templates, which can easily be dissolved under acidic conditions. After optimization of the synthesis processes, both CaCO₃ templates and PHMPs were characterized using a wide range of techniques. Then, using an array of proteins with different physicochemical properties, the encapsulation efficiency of proteins in PHMPs was evaluated under different conditions. Strategies to enhance protein encapsulation via m

SUBMITTER: Delbreil P 

PROVIDER: S-EPMC10288498 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature