Intermolecular Alkene Difunctionalization via Gold-Catalyzed Oxyarylation.

ABSTRACT: The gold-catalyzed intermolecular oxyarylation of alkenes is reported. This work employed the oxidative addition of aryl iodides to Me-DalphosAu⁺ for the formation of a Au^III -Ar intermediate. The better binding ability of alkenes over O nucleophiles ensured the success of intermolecular oxyarylation, giving desired products with a broad substrate scope and high efficiency (>50 examples with up to 95 % yield). One-pot converting of methoxy groups into other nucleophiles allowed achieving alkene difunctionalization with the construction of C-N, C-S, and C-C bonds under mild conditions.

SUBMITTER: Zhang S 

PROVIDER: S-EPMC10288501 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature