Photoswitchable Calixarene Activators for Controlled Peptide Transport across Lipid Membranes.

ABSTRACT: Supramolecular synthetic transporters are crucial to understand and activate the passage across lipid membranes of hydrophilic effector molecules. Herein, we introduce photoswitchable calixarenes for the light-controlled transport activation of cationic peptide cargos across model lipid bilayers and inside living cells. Our approach was based on rationally designed p-sulfonatocalix[4]arene receptors equipped with a hydrophobic azobenzene arm, which recognize cationic peptide sequences at the nM range. Activation of membrane peptide transport is confirmed, in synthetic vesicles and living cells, for calixarene activators featuring the azobenzene arm in the E configuration. Therefore, this method allows the modulation of the transmembrane transport of peptide cargos upon Z</

SUBMITTER: Martins JN 

PROVIDER: S-EPMC10288505 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature