Respiratory mechanics and gas exchange in an ovine model of congenital heart disease with increased pulmonary blood flow and pressure.

ABSTRACT: In a model of congenital heart disease (CHD), we evaluated if chronically increased pulmonary blood flow and pressure were associated with altered respiratory mechanics and gas exchange. Respiratory mechanics and gas exchange were evaluated in 6 shunt, 7 SHAM, and 7 control age-matched lambs. Lambs were anesthetized and mechanically ventilated for 15 min with tidal volume of 10 mL/kg, positive end-expiratory pressure of 5 cmH₂O, and inspired oxygen fraction of 0.21. Respiratory system, lung and chest wall compliances (C_rs, C_L and C_cw, respectively) and resistances (R_rs, R_L and R_cw, respectively), and the profile of the elastic pressure-volume curve (%E₂) were evaluated. Arterial blood gases and volumetr

SUBMITTER: Soares JHN 

PROVIDER: S-EPMC10288580 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature